What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? This proposed project is designed to study the diabetogenic roles and interactions of multiple GWAS-identified genes in human pancreatic beta cells. Completion of this project will provide useful information on the molecular mechanism of at least 20 GWAS-identified genes in the pathogenesis of T2D. This is potential to be transformed into clinical application in T2D therapy and contribute to finding the way to cure T2D patients carrying associated