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What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? Rates of Type 2 diabetes mellitus (T2DM) have quadrupled over the past 40 years and affects more than 400 million people. Incretin mimetics, which act to potentiate glucose-stimulated insulin secretion (GSIS), are a widely used therapeutic strategy to manage T2D. The two incretins glucagon-like peptide-1 (GLP-1) and glucose dependent insulinotropic peptide (GIP) are collectively responsible for as much as half the insulin response to a carbohydrate