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What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? My project explores previously understudied factors affecting diabetes severity. Type 2 diabetes risk is strongly influenced by genetics. My project concerns one gene, Zfp148, which affects the cells in the body that normally secrete insulin and fail in diabetes. Loss of this gene in our animal model preserves function of these cells when the mice are fed a high-fat, high-sucrose diet similar to diets which, in humans, are associated with obesity

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? Insulin resistance is a key metabolic dysfunction associated with obesity and type 2 diabetes. It happens when fat cells and tissue become inflamed. We know about things that cause inflammation and insulin resistance, but we don't know much about things that protect against them. In studies with mice, we found that when a specific gene called Dnmt3a was missing in their fat cells, they became better at using insulin and handling glucose, even on a

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? The primary goal of this project is to determine the role of two intermittent fasting approaches for treating type 2 diabetes by improving glycemic control. We will also measure how well patients comply to each intermittent fasting regimen, how feasible and tolerable the approaches are for patients with diabetes, and how well patients like either type. Lastly, we will assess an array of metabolic and behavioral factors to try and identify what

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? This project focuses on examining the potential role of gut microbiome and blood metabolites in the progression of gestational diabetes mellitus (GDM) to type 2 diabetes (T2DM). While it is widely recognized that GDM substantially increases the lifetime risk of T2DM, the mechanism remains incompletely understood. Existing epidemiological studies have shown the promise of utilizing gut microbiome and metabolomics in revealing potential biomarkers

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? My project will broadly cover multi-level efforts to improve nutrition for American Indian adults living with T2D. Multi-level includes individual and group-based diabetes nutrition education as well as improving access to healthful foods through a food security resource. This food security resource will provide supplemental healthy foods (e.g., fresh produce) to American Indian adults living with T2D who have difficulty with healthy eating because