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Targeting Fam20c, an obesity-induced kinase, for precision therapeutics of type 2 diabetes

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? This project aims to identify novel treatments for Type 2 diabetes patients with severe insulin resistance and higher body mass index ratios. These patients have high levels of adipose tissue inflammation and adipocyte dysfunction that worsens disease progression. Currently approved anti-diabetic therapies, at best, control blood glucose and can only treat the disease after it had developed. Moreover, they fail to address the root cause of

Cellular and Molecular Characterization of Human Diabetic Kidney Disease

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? My project focuses on investigating the progression of diabetic kidney disease, aiming to unravel the mechanisms leading to kidney failure. Using advanced tissue imaging modalities, we aim to characterize cellular injury within the kidney and understand the interplay between immune cells and kidney cells, crucial factors influencing kidney tissue vulnerability to disease. By elucidating the pathways associated with kidney failure in various forms

Pilot study of a culturally tailored diabetes education curriculum with real-time continuous glucose monitoring in a Latinx population with type 2 diabetes

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? Our research is focused on health disparities and how to enhance diabetes management in underserved populations. We are so excited to collaborate with our community partner, Sea Mar Community Health Centers, that works extensively with the LatinX population in Washington State. We are looking at an innovative curriculum that is culturally tailored to the LatinX community coupled with the use of continuous glucose monitoring. In order to improve

Group visits to improve technology use, glycemic control, and quality of life in high risk patients with type 1 diabetes

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? This research will help to address the significant disparities that currently exist in type 1 diabetes care and outcomes by developing shared medical visits to support the uptake and sustained use of diabetes technology among non-Hispanic Black and Latinx youth with public insurance, who historically have been least likely to access these technologies. This multidisciplinary SMA model that involves both youth and caregivers in a communal setting

Role of miR-33 in AgRP neurons and its effects on obesity and metabolic dysfunction

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? This project studies obesity and type 2 diabetes mellitus from a translational approach. It mainly focuses on obesity and diabetes prevention through the study of hunger-related neurons. We study how a small molecule could modulate the activity of these neurons modifying our feeding behavior and overnutrition affecting obesity and type 2 diabetes mellitus appearance and management. If a person with diabetes were to ask you how your project will