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TRL-driven dyslipidemia contributes beta-cell loss in type 2 diabetes

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? Our research aims to understand how elevated lipids contribute to the increased risk of diabetes. People with pre-diabetes and diabetes often have elevated lipid levels that increase their risk of heart diseases such as atherosclerotic cardiovascular disease or the build-up of lipids in the vessel wall. To reduce the risk of atherosclerotic cardiovascular disease, many people with diabetes are treated with a class of lipid-lowering medications

Community settings approach to prevention, education and screening of diabetes.

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? My project leverages community partnerships to screen for diabetes risk (i.e., prediabetes) among a highly disparate and vulnerable population (i.e., Black women). In using hair stylists to identify those at high risk for diabetes and providing referral to extant diabetes prevention programming, this study uses innovative strategies that utilize community allies to increase access to preventive services. This project will increase access to

Interrogating the role of T1D-associated genetic variants on T cell phenotype and function

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? My research project centers around the genetics of Type 1 Diabetes (T1D), in particular how the genes associated with risk for T1D may impact T cell function. T cells are thought to be important mediators of insulin producing beta cell destruction, as such there are many therapeutics under investigation to target these cells, one of which is the sole FDA approved therapeutic for disease delay, Teplizumab. Although multiple lines of evidence

Developing novel predictive and monitoring biomarkers of diabetic foot ulcers from discarded wound dressings

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? Our research focuses on understanding diabetic foot ulcers (DFUs) and how we can develop targeted therapies to accelerate wound closure in these non-healing chronic wounds. The current project aims to first develop and then validate biomarkers of non-healing DFUs that could serve to either predict healing outcome or diagnose trajectory of healing. Our aim is to develop "smart" dressings which could communicate by any phone/hand-held device via

Prevention and treatment of fructose-induced insulin resistance by dietary fibers

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? This project investigates the role of dietary fibers in dealing with the harmful effects of high fructose corn syrup, commonly found in sodas and processed food. This is known to cause poor management of blood sugar and lipid levels in the liver, leading to detrimental diseases like diabetes and fatty liver. This project is particularly interested in how these dietary fibers interact with the gut bacteria and how this can influence sugar levels in