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What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? My obesity and diabetes precision medicine research project proposes to investigate novel mechanisms mediating the brain’s control of energy homeostasis and blood glucose in pre-clinical rodent models of energy dysregulation, and moreover, translate these findings to humans. The focus of my project aims to understand how the extracellular matrix surrounding energy-sensing neurons in the mediobasal hypothalamus can influence the activity and/or