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What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? Diabetes results in high sugars that damage small blood vessels throughout the body. This can lead to dysfunction of multiple organs including the brain, eyes, heart, kidneys, and nerves. Proper small vessel function is critical for oxygenation and nutrient delivery. The mechanisms that drive small vessel damage are clearly complicated and incompletely understood. A significant barrier is cause by the complex organization of small vessels, which

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? The current project will develop a multifaceted risk detection system based on the extant literature and our own available data on patient-reported outcomes (PROs) and from clinical laborites and medical charts. It will be designed to offset glycemic and mental health risk as well as promote personalized diabetes treatment recommendations and resources. The system will include components necessary to precisely detect risk across three primary

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? Diabetes self-management education and support programs (DSMES) can help people living with diabetes to choose food and activities to lower their blood sugar, reduce costs associated with diabetes, and ultimately improve health and lower the chance of developing other problems such as stroke or blindness. However, not all people with diabetes are referred to or participate in DSMES programs. There is a need to understand and reduce the barriers to

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? My project covers precision treatment for type 2 diabetes in older adults. This particular project uses cutting-edge machine learning and epidemiological methods to analyze big data (e.g., US Medicare database) to discover subpopulation that may experience more benefit or adverse events for a given treatment, leading to a tailored treatment for a specific patient and, ultimately, better individual and population outcomes. This project will prevent

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? The day-to-day management of type 1 diabetes demands much more of patients than simply insulin dosing and glucose monitoring. A fundamental aspect of comprehensive and person-centered type 1 diabetes care includes addressing the complex social, emotional, behavioral, and environmental factors that affect both mental and physical health of people living with diabetes. Psychosocial and behavioral interventions (i.e., interventions with psychological

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? My research is intended to study the mechanisms by which type 2 diabetes develops in children with obesity. Approximately 1 in 4 children in the US have a BMI which qualifies for obesity, which places them at particular risk for development of type 2 diabetes and its complications, more so than when obesity begins in adulthood. Studies in adults suggest that dysfunction of fat tissue (adipose) is a stronger predictor of insulin resistance and

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? My project relates to the fields of incretin signaling, nutrigenomics, metabolite profiling and pharmacogenomics within the greater field of diabetes precision medicine. My goal is to characterize the mechanisms and influence of genetic background and circulating metabolites on human glucagon-like peptide-1 (GLP-1) response to a meal and how this response is modified by acute metformin treatment. Our findings on genetic and metabolic