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What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? This study will address disease heterogeneity in patients with type 1 diabetes (T1D) by studying a recently identified population of T cells with stem-like properties that are expanded in a subset of T1D patients to determine their relationship to the disease process. The results will provide valuable knowledge on mechanisms underlying disease heterogeneity which is essential for accurately predicting disease progression, stratifying patients for

What area of diabetes research does your project cover? What role will this particular project play in preventing, treating and/or curing diabetes? My research projects mainly focus on the gene mutation and obesity development, which can result in Type 2 diabetes. Specifically, this project will focus on the TRPC5 gene that we firstly identified recently, which is the most strongly associated X-linked gene for human body mass index (BMI). I found that loss of function TRPC5 mutations can cause human obesity, and this gene should be included in the genetic diagnostic panel for obesity. The open