Postprandial Hyperglycemia and/or Hyperinsulinemia Is Associated with Cardiovascular Risk Factors in Healthy Male Subjects

Postprandial Hyperglycemia and/or Hyperinsulinemia Is Associated with Cardiovascular Risk Factors in Healthy Male Subjects Using the measurements in medi Using the measurements in medical check-up with 75g-OGTT, we investigated associations between cardiovascular risk factors and plasma levels of glucose (PG) and insulin (PI) in healthy male subjects (n=620) who were not taking any medications known to affect glucose tolerance, blood pressure (BP) or plasma lipids. According to 2003 ADA criteria, subjects were classified as NFG/NGT (N, n=499), isolated IFG (iIFG, n=63), isolated IGT (iIGT, n=29), and combined IFG and IGT (IFG/IGT, n=29). Insulin action was evaluated by HOMA-IR (an index of hepatic insulin resistance) and Matsuda index (an index of whole body insulin sensitivity) {=10,000/ [(FPGxFPI)x(meanPGxmeanPI)][sup]1/2[/sup]} calculated from the OGTT. Age and BMI were similar in all 4 groups. HOMA-IR was higher in iIFG (2.38) and IFG/IGT (2.58) compared with N (1.79) (p[lt]0.05). Matsuda index was lower in iIFG (6.74), iIGT (6.26) and IFG/IGT (5.01) compared with N (9.94) (p[lt]0.05). Mean BP (MBP) was higher in iIGT (101mmHg) versus N (92mmHg) (p[lt]0.01). Plasma triglyceride (TG) level and TG/HDL ratio were higher in IFG/IGT versus N (173 vs. 128mg/dl and 3.99 vs. 2.78, both p[lt]0.01), although HDL, LDL and LDL/HDL ratio were similar in the groups. In backward stepwise multiple regression analysis using age, BMI, PG and PI at 0, 60, 120 min during the OGTT as independent variables, increases in BMI, PG[sub]120[/sub] and PI[sub]60[/sub] were independently related to increases in MBP (p[lt]0.0001) and TG/HDL ratio (p[lt]0.0001). Increases in BMI and PI[sub]60[/sub] were independently related to an increase in LDL/HDL ratio (p[lt]0.0001). Matsuda index inversely correlated to MBP (r=-0.19, p[lt]0.001), TG/HDL ratio (r=-0.15, p[lt]0.001) and LDL/HDL ratio (r=-0.15, p[lt]0.01), although HOMA-IR positively correlated to only MBP (r=0.13, p[lt]0.01) but not to TG/HDL ratio or LDL/HDL ratio. These results indicate that postprandial hyperglycemia and/or hyperinsulinemia due to the impairments of whole body insulin sensitivity in addition to obesity are closely related to risk factors of atherosclerotic macrovascular disease in pre-diabetic male subjects. YOSHINORI MIYAZAKI, MAKOTO FURUGEN, HIROSHI AKASAKA, SHIGEYUKI SAITOH, TETSUJI MIURA 522-P Muroran, Japan, Sapporo, Japan Complications - Macrovascular - Atherosclerotic Cardiovascular Disease and Human Diabetes