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Recommended pharmacological therapy for hyperglycemia in type 2 diabetes1 is summarized on three slides Slide 1 of 3 Metformin, if not contraindicated and if tolerated, is the preferred initial pharmacological agent for type 2 diabetes (A) In newly diagnosed type 2 diabetic patients with markedly symptomatic and/or elevated blood glucose levels or A1C, consider insulin therapy, with or without additional agents, from the outset (E) The ADA and EASD have recently partnered on guidance for individualization of use of medication classes and combinations in patients with type 2 diabetes2 This 2012 position statement is less prescriptive than prior algorithms and discusses advantages and disadvantages of the available medication classes and considerations for their use A patient-centered approach is stressed, taking into account patient preferences, cost and potential side effects of each class, effects on body weight, and hypoglycemia risk50References American Diabetes Association. Standards of medical care in diabetes—2013. Diabetes Care 2013;36(suppl 1):S22. Inzucchi SE, Bergenstal RM, Buse JB, et al.; American Diabetes Association (ADA); European Association for the Study of Diabetes (EASD). Management of hyperglycemia in type 2 diabetes: a patient-centered approach. Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012;35:1364-1379