Recommendations: Insulin Therapy for Type 1 Diabetes (1)
Recommendations for insulin therapy for type 1 diabetes1 are shown on two slides Slide 1 of 2 Most people with type 1 diabetes should be treated with MDI injections (3–4 injections per day of basal and prandial insulin) or continuous subcutaneous insulin infusion (CSII)1 (A) The DCCT clearly showed that intensive insulin therapy was a key part of improved glycemia and better outcomes2,3 At the time of the study, therapy was carried out with short- and intermediate-acting human insulins Despite better microvascular outcomes, intensive insulin therapy was associated with a high rate in severe hypoglycemia (62 episodes per 100 patient-years of therapy)48References American Diabetes Association. Standards of medical care in diabetes—2013. Diabetes Care 2013;36(suppl 1):S21. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977-986. Nathan DM, Cleary PA, Backlund JY, et al for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 2005;353:2643-2653.