Diabetes Care in the Hospital: NICE-SUGAR Study (1)
Results of the NICE-SUGAR study1,2 are summarized on two slides Slide 1 of 2 Hyperglycemia in the hospital may result from stress; decompensation of type 1, type 2, or other forms of diabetes; and/or may be iatrogenic due to withholding of antihyperglycemic medications of administration of hyperglycemia-provoking agents such as glucocorticoids or vasopressors There is substantial observational evidence linking hyperglycemia in hospitalized patients (with or without diabetes) to poor outcomes The largest study to date, NICE-SUGAR, a multicenter, multinational randomized controlled trial, compared the effect of intensive glycemic control (target 81–108 mg/dL, mean blood glucose attained 115 mg/dL) to standard glycemic control (target 144– 180 mg/dL, mean blood glucose attained 144 mg/dL) on outcomes among 6,104 critically ill participants, almost all of whom required mechanical ventilation2139References American Diabetes Association. Standards of medical care in diabetes—2013. Diabetes Care 2013;36(suppl 1):S46. Finfer S, Chittock Dr, Su SY, et al for the NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360:1283-1297.