Low adiponectin serum levels predict future diabetes in postmenopausal women
June - 22 - 2011
The link between obesity and type 2 diabetes is well-established. Adiponectin is a protein produced by adipocytes and plays an important role in lipid metabolism and insulin secretion. The role of serum adiponectin concentrations in predicting future type 2 diabetes and its association with insulin sensitivity and beta-cell functioning were investigated in a prospective, population-based study. The cohort consisted of 500 Caucasian females aged 64 years. Evaluations included adiponectin serum levels, insulin sensitivity (using homeostasis model), glucose tolerance, lifestyle factors and C-reactive protein (CRP). At baseline, 159 subjects had diabetes, 174 had impaired glucose tolerance (IGT) and 167 had normal glucose tolerance (NGT). During the follow-up period of 5.5 years, 69 new type 2 diabetes cases were diagnosed. High adiponectin levels were correlated with high insulin sensitivity at baseline. Those who developed diabetes during the follow-up period had lower adiponectin levels at baseline compared to those who remained without diabetes. Independent predictors of incident diabetes were low adiponectin levels, insulin resistance and secretion, baseline IGT and impaired fasting glucose and unhealthy lifestyle (smoking and abdominal obesity). The study demonstrated the prognostic value of adiponectin serum levels in predicting future diabetes in this patient population, independent of insulin sensitivity status and lifestyle factors (Fagerberg, B. et al. J Intern Med 2011, 269(6): 636).