HbA1c may have some diagnostic value in gestational diabetes mellitus
March - 31 - 2011
The diagnostic value of glycated hemoglobin (HbA1c) measurements as one of the criteria for gestation diabetes mellitus (GDM) was investigated in a Swedish study of 96 pregnant women. The study evaluated the correlation between HbA1c, and results of oral glucose tolerance test (OGTT) postglucose challenge plasma glucose and estimated average plasma glucose (ePG). GDM status was based 2-hour OGTT capillary glucose value of 10.0 mmol/L or more. Subjects with GDM underwent HbA1c assessment and were prescribed glycemic self-monitoring. Mean HbA1c was 4.27%; mean OGTT glucose and ePG were 10.7 and 6.0 mmol/L, respectively. Glycemia was controlled through dietary strategies in 64 subjects, whereas insulin therapy was prescribed for 32 subjects. Correlations between HbA1c and OGTT and mean eAG were significant, indicating the HbA1c could be used as a diagnostic tool for GDM. Of the three measurements, the necessity of insulin treatment was best predicted by mean ePG (Landin-Olsson, M. et al. 6th Int Symp Diabetes Pregnancy (March 23-26, Salzburg) 2011, Abst 255).