Diastolic Dysfunction in Patients With Diabetes Linked to HF, Increased Mortality Risk
January - 22 - 2010
Patients with diabetes and preclinical diastolic dysfunction have a greater likelihood of developing heart failure (HF) and a higher risk of mortality, according to a population-based study of 1,760 people. The patients all had diabetes and diastolic function identified by tissue Doppler echocardiography. Preclinical diastolic dysfunction without a HF diagnoses was identified in 411 of the patients. According to the authors, those with both diabetes and diastolic dysfunction were more likely to be older, female, and with an increased prevalence of hypertension and coronary artery disease. The study results suggest that the risk of developing HF increased by 3 percent for every one-unit increase in the mitral E/e' ratio. The probability of HF development in patients with both diabetes and diastolic dysfunction was 13.1 percent at one year and 36.9 percent at five years, compared to 5.2 percent at one year and 16.8 percent at five years for the patients without diastolic dysfunction.