A Short Bout of Stair Climbing and Descending Exercise Ameliorates Postprandial Hyperglycemia in Elderly Adults with T2DM
Abstract Number: 2165-PO
Authors: TETSUO TAKAISHI, TATSUYA HAYASHI
Institutions: Nagoya, Aichi, Japan, Kyoto, Japan
Results: Exercise is a potent stimulator of glucose uptake in skeletal muscle. This strategy is utilized to improve glycemic control in patients with DM because contraction-stimulated glucose uptake is not impaired in insulin-resistant or -deficient conditions. The present study was designed to evaluate the acute hypoglycemic effect of stair climbing and descending exercise (ST-EX) on postprandial hyperglycemia. Eight non-complicated T2DM subjects (3 men and 5 women, age 71.1 ± 3.7 y, BMI 21.7 ± 3.0 kg/m2, fasting blood glucose 97 ± 20 mg/dl, HbA1c 6.5 ± 0.8 %; means ± SD) were enrolled. Five subjects were managed with oral hypoglycemic agents, which were discontinued on the experimental day. On separate days, 5 h after breakfast, the subjects ingested a carbohydrate beverage containing 30 or 50 g of starch hydrolysate, and then (1) kept sitting on a chair for 120 min (REST), (2) kept sitting for 90 min, then performed a brisk walk for about 6.5 min and then kept sitting until 120 min (WALK), or (3) kept sitting for 90 min, then performed ST-EX for about 6.5 min and then kept sitting until 120 min (STAIR). ST-EX comprised 12 sets of climbing a stairway to a second floor (18 cm height, 21 steps) at the rate of 80-120 steps/min followed by walking down the stairs slowly to the first floor. At 90 min after ingestion, blood glucose levels (BG90) were not different among the conditions (REST 240 ± 33, WALK 220 ± 47, STAIR 218 ± 42 mg/dl, NS; means ± SD). However, blood glucose decreased more rapidly in STAIR than other conditions, particularly shortly after exercise (DBG105-BG90: REST -21 ± 11, WALK -34 ± 9, STAIR -61 ± 16** mg/dl, **P < .01 vs. REST and WALK; DBG120-BG90: REST -59 ± 28, WALK -59 ± 27, STAIR -72 ± 23 mg/dl, NS; means ± SD). Heart rate and blood lactate level were 96 ± 15 beats/min and 1.6 ± 0.5 mmol/l at the end of walking, and 125 ± 18* beats/min and 4.0 ± 1.1* mmol/l at the end of ST-EX, respectively (means ± SD, *P < .05 vs. walking). All the subjects completed ST-EX without significant symptoms such as dyspnea and leg fatigue. We propose that a short bout of ST-EX is a safe and useful modality to improve glucose excursions after meals.