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Abstract

Click to add/remove this article to your list of 'My Favorites' Domain-Specific Cognitive Function and Fine Motor Speed in Women 65 Years and Older with Type 2 Diabetes Mellitus: Results from the Women's Health Initiative Study of Cognitive Aging

Year: 2011

Abstract Number: 253-OR

Authors: MARK A. ESPELAND, MICHAEL E. MILLER, JOSEPH S. GOVEAS, PATRICIA E. HOGAN, LAURA H. COKER, JEFF WILLIAMSON, MICHELLE NAUGHTON, SUSAN M. RESNICK

Institutions: Winston-Salem, NC, Milwaukee, WI, Baltimore, MD

Results: We examined whether Type 2 diabetes mellitus (T2DM) was associated with accelerated decline in global cognitive function, six domain-specific measures of cognitive function, and fine motor speed. Women aged 65-80 years who were enrolled in a clinical trial of postmenopausal hormone therapy were grouped as having T2DM (N=179) or not (N=1,984) and followed with annual standardized assessments of domain-specific cognitive function for an average of 5 years. Mean patterns of cognitive measures over time were contrasted between groups using general linear models and Wald tests, with varying levels of covariate adjustment. The influences of age at onset, use of oral medications, and use of insulin were also examined. T2DM was associated with mean deficits of 0.2 to 0.4 standard deviations across follow-up in most cognitive domains. Consistent evidence that rates of decline were accelerated among women with T2DM was evident only for verbal knowledge and verbal memory (p<0.05). Decrements in fine motor speed, but no measure of cognitive function, were greater for women with earlier onset T2DM. Among women with T2DM, treatment with oral diabetes medications alone was associated with better overall cognitive function, with scores similar to those for women with no T2DM. In sum, T2DM was associated with lower cognitive performance in most domains. Group differences in rates of change suggest that relative deficits in verbal knowledge and verbal memory may continue to increase after deficits in other domains have stabilized.[figure1]

Category: Epidemiology

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