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Click to add/remove this article to your list of 'My Favorites' Correlation between Autonomic Neuropathy and Distal Peripheral Neuropathy and Its Coassociation with Peripheral Vascular Disease in Type-2 Diabetes Mellitus Patients

Year: 2010

Abstract Number: 2272-PO


Institutions: New Delhi, Delhi, India

Results: Objective:

This study was designed as prospective,noninterventional,observational,unicentre study to find correlation between autonomic neuropathy and peripheral neuropathy and then to identify association if any between autonomic neuropathy and peripheral vascular disease (PVD) in type-2 diabetes patients.


60 patients with type-2 diabetes mellitus were studied. 30 patients with diabetic peripheral neuropathy comprised of test group while 30 patients without peripheral neuropathy constituted the control group. Patients with nephropathy, CAD, CVA, gross dyslipidemia, Buerger's disease were excluded. All subjects were assessed for autonomic neuropathy using Ewings battery of tests and peripheral arterial doppler was performed to evaluate PVD.



Test Group


Control Group


Early Parasympathetic dysfunction

    8      1

Definite parasympathetic dysfunction

    22      9

Definite parasympathetic dysfunction & Sympathetic dysfunction

    13      4 

Peripheral Vascular disease

    10      2 

Definite parasympathetic dysfunction & Peripheral Vascular disease

     9       2 
73.33% patients with peripheral neuropathy (Test Group) had evidence of Diabetic Autonomic neuropathy . 26.67% patients in the test group also showed early parasympathetic dysfunction. Mean CAN score in the test group was 4.133, and SD + 2.677. In the control group without peripheral neuropathy 30% patients had definite autonomic neuropathy while one patient had early parasympathetic dysfunction. Mean CAN score in the control group was 1.733, and S.D. + 1.94. 10 patients in the test group and 2 patients in control group had evidence of PVD on Doppler assessment of lower limb vessels. Eleven (91.67%) of these twelve patients had definite autonomic dysfunction and early parasympathetic dysfunction was found in one patient.


There is a strong positive correlation between autonomic neuropathy and peripheral neuropathy (p value - .00014). A strong association between PVD and autonomic neuropathy was seen but a statistical correlation was not documented as small number of subjects suffered from PVD.

Category: Neuropathy