A Low Glycemic and Insulinemic Diet (LOGI®) and Moderate Physical Training Improve Cardiac Function and Metabolic Syndrome in Spite of a 70% Reduction of Antidiabetic Therapy
Abstract Number: 372-OR
Authors: HELENE VON BIBRA, GODEHART WULF, PETER HEILMEYER
Institutions: Munich, Germany, Isny, Germany
Results: Diastolic cardiac dysfunction in people with metabolic syndrome and type 2 diabetes (D) may be improved by optimizing metabolic control by medical therapy. We tested the hypothesis that, by lowering postmeal glucose levels, LOGI® exerts superior effects on cardiac function and metabolism in these patients compared to the traditional low fat diet (LoFa).
25 D patients on oral antidiabetic therapy (OAD, n=20) or diet (n=5) without heart disease were studied before and after a 3-week rehabilitation programme with LOGI and compared to 16 D patients on isocaloric LoFa. Systolic (S') and diastolic (E') myocardial velocity was measured by pulsed tissue Doppler. Metabolic control was assessed before and 2 h after a standardized breakfast (400 kcal) with LoFa at baseline (carbohydrate 55%, fat 25% and protein 20%) and LOGI composition (25%, 45% and 30%, respectively) at the final test for the LOGI group. Both groups had supervised aerobic training 2 hours a day.
After LOGI diet, HbA1c (p<0.0001), fasting glucose (p<0.001) and postmeal glucose (144 ± 52 to 123 ± 34 mg/dl, p<0.01) decreased although OAD was reduced by 70%. Cholesterol (p<0.04) and triglycerides decreased (192 ± 131 to 145 ± 81 mg/dl, p<0.001). Weight parameters decreased (p<0.001). Physical work capacity increased by 20% (p<0.004) whilst blood pressure decreased (p<0.003). S' increased (p<0.05) and so did E' from 9.6 ± 1.1 to 10.5 ± 1.4 cm/s (p<0.001) into the normal range. After LoFa, there were similar reductions in weight, HbA1c, fasting glucose and cholesterol. But postmeal glucose and triglycerides were unchanged whilst OAD was reduced by 30%. S', E' and blood pressure remained unchanged.
In overweight people with D during a 3 weeks rehabilitation programme, LOGI® but not the traditional low fat diet improved postmeal glucose levels, triglycerides, blood pressure and cardiac function. The associated 70% reduction of OAD may be of interest for a reduction of public health costs.