Maternal Transmission of Type 2 Diabetes in Greek Diabetic Subjects
Abstract Number: 1008-P
Authors: ALEXIOS SOTIROPOULOS, ATHANASIA PAPAZAFIROPOULOU, ANTHI KOKOLAKI, OURANIA APOSTOLOU, STAVROS BOUSBOULAS, MARINA KARDARA, STAVROS PAPPAS
Institutions: Nikaia, Greece
Results: It is known that familial history is a major risk factor for the developing of type 2 diabetes mellitus (T2DM). Previous studies in different racial groups have reported higher prevalence of diabetes among mothers of subjects with T2DM than among fathers. However, the literature data regarding our country are limited. Therefore, we contacted the present study in order to examine the existence of maternal transmission of T2DM in Greek diabetic subjects.
A total of 1,153 subjects with T2DM were recruited. All patients (547 men / 606 women, mean age ± SD: 67.3 ± 11.7 years, duration of T2DM ± SD: 13.4 ± 9.1 years) underwent standardized clinical and laboratory investigations. Study subjects answered a questionnaire about familial history of T2DM (mother, father, siblings).
Of the study patients, 52.7% reported at least one first-degree affected familial member, 32.5% of the patients reported only a diabetic mother compared to 16.9% who reported only a diabetic father (χ2= 118.25, P<0.001). 4.2% of the study subjects presented with both parents and 9.6% with siblings with T2DM. Subjects with maternal history of T2DM showed a higher frequency of nephropathy than individuals with paternal history (4.7% versus 0.8%, respectively, P=0.04). On the contrary, subjects with paternal history showed higher frequency of hypertension than individuals with maternal history (71.4% versus 60.1%, respectively, P=0.03). The study groups did not differ in terms of age at T2DM diagnosis and HbA1c levels, presence of coronary disease, retinopathy and dyslipidemia, regarding their maternal or paternal history of T2DM.
The present study showed that there is a significant maternal effect in the transmission of T2DM in Greek diabetic subjects. Individuals with maternal transmission of T2DM showed higher frequency of nephropathy and lower frequency of hypertension than individuals with paternal history of T2DM.