Can a Single High-Fat Meal Impair Endothelial and Autonomic Function?
Abstract Number: 71-LB
Authors: CHUMJIT CHARASURAISIN, Loma Linda, CA
Institutions: Loma Linda, CA
Results: A major marker for diabetes is chronic inflammation due to visceral obesity. It is known that a chronic high-fat diet is directly responsible for endothelial dysfunction and exacerbation of diabetes. However, the effect of an acute single high-fat meal on endothelial and autonomic function is not well understood and needs further investigation. Therefore, the purpose of this study was to determine the effect of a single high-fat (HF) versus low-fat (LF) meal on endothelial and autonomic function. Nineteen healthy subjects participated in a randomized controlled breakfast cross-over feeding study (mean age 26.6 ± 4.4 years, mean BMI 24.5 ± 1.62 kg/m2). Endothelium dependent vasodilation was assessed in the forearm using Whitney strain gauge Plethysmography (BF). Skin flows (SF) were measured by Laser Doppler flowmetry. Blood pressure (BP), heart rate (HR), cardiac work, and arterial resistance were used to assess autonomic function. Subjects fasted the night before the experiment and were randomly fed either a HF (50.1g total fat) or a LF (5.1g total fat) meal with a one week interval before crossover to the alternate breakfast-meal. BF and cardiovascular measurements were taken at multiple baselines and at 2-and 4-hours following the test meal. After the LF meal , resting BF at 4-hour postprandial was significantly increased (p=0.029) compared to the baseline. Two-and 4-hour postprandial peak and excess BF were significantly increased from baseline (p=0.0019 and p<0.0001, respectively). HR and cardiac work (HR x BP) were significantly increased (p<0.05 and p=0.03, respectively) after the LF meal ingestion. Mean BP during hyperemia at 2-hr postprandial increased (p=0.0016) whereas forearm vessel resistance decreased (p=0.0015), compared to baseline. No endothelial or autonomic function change was found in either BF or cardiovascular measures subsequent to HF meal ingestion. Our findings show that a single HF meal ingestion can impair endothelial and autonomic function for at least up to 4 hours. The extrapolation to a pattern of high fat meal ingestions, as present in the typical American diet is likely to have profound implications for diabetes and CVD.
Category: Nutrition - Clinical