The Association between the Ferritin Concentration, and Serum Insulin Resistance, Secretion Markers, and Follow-Up Analysis for Three Years in Nondiabetic Japanese Men
Abstract Number: 1007-P
Authors: NAOTAKE HASHIMOTO, YOSHIFUMI SUZUKI, ATSUYA HORIE, TAKENORI HARUKI, YUKIE SAKUMA, RIE IWAI, HIDENORI TAKAHASHI, Yachiyo, Japan, Asahi, Japan
Institutions: Asahi, Japan; Yachiyo, Japan
Results: Several studies have reported that serum ferritin concentrations may be an independent marker for insulin resistance. To clarify the role of iron store on insulin resistance, secretion, and glucose tolerance in Japanese population, we studied analyzing correlations of serum ferritin concentration with serum metabolic markers for 3 years in Japanese subjects participating in a health screening program. Subjects and Methods: We selected the 194 subjects with no medical treatment, who attended the health screening program once a year for subsequent three years and analyzed in 141 men, because serum ferritin level are changeable in women to menstruation. The subjects were grouped by serum ferritin concentrations at the first year (low, < 80 ng/ml; middle, 80 to 150; high, >150). Results: In basal analysis at the first year, serum ferritin concentration correlated positively with fasting plasma glucose (FPG) (r=0.334, P<0.0001), fasting plasma insulin (FIRI) (r=0.390, P<0.0001), fasting plasma C-peptide (FCPR)(r=0.381, P<0.0001), HOMA-R (r=0.403, P<0001), HOMA-β (r=o.24, P<0.001).
In the high serum ferritin group (H)(n=39), serum ferritin concentration were higher at the second, and the third year than in middle(M)(n= 52) and low groups(L)(n=50). In H group, FPG was significantly higher at the second and third year than in other groups. FIRI, FCPR, HbA1c, HOMA-R, HOMA-β were significantly higher at the second and third year than other groups. The ratio of FCPR and FPG in H group was slightly decreasing at the second and third year, but there was not significant difference. Conclusions: In nondiabetic male Japanese subjects, serum ferritin concentration was one of the stable clinical markers for insulin resistance and compensated increased insulin secretion, and the insulin resistance persisted for at least three years in the high group in ferritin concentration. In this group, there may be high prevalence for onset of diabetes through the persistence of insulin resistance and relatively deterioration of insulin secretion capacity.