Dietary Glycemic Index, Glycemic Load, Cereal Fiber and Plasma Adiponectin Concentration in Diabetic Men
Abstract Number: 1005-P
Authors: LU QI, ERIC RIMM, SIMIN LIU, NADER RIFAI, FRANK B. HU
Institutions: Boston, MA
Results: Adiponectin is a newly identified bioactive molecule that is secreted by adipose tissue and is abundantly present in circulation. It has been found that adiponectin may improve insulin sensitivity, reduce inflammation, improve glycemic control, and ameliorate lipid metabolism in both general population and diabetic patients. However, few studies have evaluated dietary predictors of plasma adiponectin levels, especially among subjects with type 2 diabetes. This study included 780 diabetic men in the Health Professionals' Follow-up Study. After adjustment for age, BMI, smoking, alcohol consumption, physical activity, aspirin use, HbA1c, history of hypertension or hypercholesterolemia, and fiber intake, dietary glycemic index and glycemic load (1986 to 1994) were inversely associated with plasma adiponectin in a dose-dependent fashion (P for trend, 0.005 for glycemic index; and 0.004 for glycemic load). Adiponectin levels were 13% lower in the highest quintile of dietary glycemic index as compared with the lowest quintile. For dietary glycemic load, adiponectin levels were 18% lower in the highest quintile as compared with the lowest. In contrast, high intake of cereal fiber was associated with increased plasma adiponectin levels, adjusting for lifestyle factors and dietary glycemic load (P for trend=0.003). Adiponectin levels were 19% higher in the highest quintile compared to the lowest quintile. Higher magnesium intake was also associated with increased plasma adiponectin. We conclude that, diets low in glycemic load and high in fiber may improve plasma adiponectin concentrations in diabetic patients.