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Click to add/remove this article to your list of 'My Favorites' The Relation of Baseline Body Fat and Body Fat Distribution Measured by Computed Tomography (CT) to the Development of Diabetes in the Diabetes Prevention Program

Year: 2005

Abstract Number: 1002-P


Institutions: Rockville, MD

Results: Visceral and subcutaneous fat measured by CT in DPP participants were used to test the hypothesis that greater visceral and subcutaneous fat increases the risk of the development of diabetes in individuals with impaired glucose tolerance. CT scans at the L2-3 and L4-5 region were obtained at baseline in a substudy of 1106 patients. 947 had complete sets of scans at both locations. After completion of baseline measures, participants were randomized to placebo, metformin or a lifestyle-modification program. We used sex-specific proportional hazards models using baseline fat measurements adjusted for age, ethnicity, and treatment group to predict the development of diabetes over an average of 3.2 years of follow-up (Table). In conclusion, greater visceral fat was a strong predictor for the risk of developing diabetes in both men and women. In contrast, subcutaneous fat was predictive in men but only in the L4-5 CT cut. Waist circumference had the largest hazard ratio (HR) in men, while visceral fat at L2-3 had the largest HR in women.

Mean ± SDHR (95% CI)*Mean ± SDHR (95% CI)*
Visceral Fat (cm2)L2-3261±87.71.46 (1.10-1.92)165±63.21.37 (1.13-1.65)
L4-5179±73.61.33 (1.04-1.71)149±57.41.29 (1.08-1.38)
Subcutaneous Fat (cm2)L2-3251±1101.24 (0.94-1.63)334±1251.00 (0.81-1.23)
L4-5350±1271.39 (1.08-1.79)485±1430.97 (0.80-1.18
BMI (kg/m2)32.1±5.21.37 (1.13-1.66)33.6±6.01.08 (0.87-1.32)
Waist (cm)108±12.01.53 (1.14-2.04)101±13.01.12 (0.91-1.38)
* HR=Hazard ratio per 1 SD

Category: Epidemiology