Long-Term Aerobic Exercise Can Potentiate the Effect of Rosiglitazone on Islet Preservation and Insulin Resistance in Diabetic Prone OLETF Rat Model
Abstract Number: 1002-P
Authors: MOONSUK NAM, IN-SUN PARK, SUN-HEE PARK, JAE H. EARM, WAN S. SHIM, SEONG B. HONG, YONG S. KIM.
Institutions: Incheon, Republic of Korea.
Results: Steady aerobic exercise is recommended for diabetes treatment with anti-diabetic medications, particularly thiazolidinediones in obese type 2 diabetes. We evaluated the effects of aerobic exercise (20 m/min, 30 minutes/day) and rosiglitazone (3mg/kg/day) for 24 weeks on islet morphology and insulin resistance in obese diabetic prone animal model, OLETF(Otsuka Long Evans Tokushima Fatty) rat.
Increased lean body mass, decreased epididymal fat, and improved intraperitoneal glucose tolerance test were observed in both rosiglitazone plus exercise and exercise only groups (each group n=15). And the onset of diabetes was also delayed in both exercise and rosiglitazone group compared with control. On the chronological changes of islet morphology, more significant decrease of beta cell destruction was shown in rosiglitazone plus exercise group compared with exercise or rosiglitazone only. And aerobic exercise therapy led to extension of normal expressions of insulin secretion and GLUT-2 to the level of rosiglitazone group with Western blot analysis and confocal microscopic finding, indicating comparable preventive or therapeutic effects of exercise with rosiglitazone treatment.
We suggest exercise is an essential regimen for islet preservation and improving insulin resistance in obese type 2 diabetes, particularly for anti-diabetic treatment with rosiglitazone.