A Correlation between Dehydroepiandrosterone-Sulfate and Erectile Dysfunction in Diabetes
Abstract Number: 2148-PO
Authors: HIDEKATSU SUGIMOTO, TOSHIHIKO YANASE, HAJIME NAWATA
Institutions: Kitakyushu, Fukuoka, Japan; Fukuoka, Fukuoka, Japan
Results: Among male DM, erectile dysfunction (ED) is one of the matters of concern. While causes of ED is not clear, a biochemical parameter might be useful to evaluate and study ED in DM. There are several reports that serum level of Dehydroepiandrosterone-sulfate (DHEA-S) may correlate to aging. In this study, a correlation between DHEA-S and libido in male DM was investigated and some other factors were discussed also. 221 male DM (62.9±10.5yrs, M±SD) handed questionnaires, asking sex life, to male doctor personally. One-year averages of HbA1c,blood pressure,total cholesterol (TC), HDL-C were adopted. Furthermore CVrr on ECG, Homa-R as an index of insulin resistance in type2 DM and some complications were also discussed. DHEA-S was measured by RIA. DHEA-S of DM with active sex life (ACT) was 1647±972 ng/mL (N=143) significantly higher than that with inactive sex life (INACT), 1072±599 (72), p <0.001. As negative correlation between age and DHEA-S was observed (r = -0.41, P<0.001), age 60s of both groups were discussed. DHEA-S of ACT of 60s was 1457±667 (52)higher than that of INACT 1066±575 (24), p=0.016. DHEA-S was positively correlated with diastolic BP (r=0.24), TC (0.15), CVrr (0.19) and Homa-R (0.30), (p=0.001, 0.025, 0.008, 0.006 respectively). DHEA-S was assumed as dependent variable and age, BMI, diastolic BP, TC, CVrr and Homa-R were as independent variables, then multiple linear regression was calculated. Only Homa-R had a significantly independent correlation (p=0.042) . When a sexual activity of 60s was discussed, a non-parametric correlation method was adopted with age, BMI, retino-, nephro-, peripheral neuropahty,BP,TC, HDL-C,HbA1c,DHEA-S,CVrr and Homa-R. An activity of sex life (ACT or INACT)was positively correlated with DHEA-S and CVrr. In conclusion, DHEA-S is lowering as aging and also decreased with an existence of autonomic neuropathy. A result related to Homa-R suggests that a secretory ability of insulin in type 2 DM may preserve a serum DHEA-S. And libido may be decreased by a low DHEA-S and by an existence of autonomic neuropathy.