"The Linosa Study": Epidemiology of Metabolic Syndrome in a Caucasian Genetic Isolate
Abstract Number: 961-P
Authors: ALFONSO BELLIA, PAOLO SBRACCIA, MASSIMO FEDERICI, DAVIDE LAURO, MANFREDI TESAURO, GASPARE CUSUMANO, RENATO LAURO
Institutions: Rome, Italy; Palermo, Italy
Results: The groups that are most likely to yield the genetics of complex diseases are isolated populations with strong founder effects. The population of Linosa, a small Italian island in the Mediterranean sea, is a genetically well-defined isolated group with a high degree of consanguinity (n=352; 155 men, 197 women; aged 5-97 years; mean 48±19.7 DS; median 47); this is a rural-sea population adherent to a typical Mediterranean diet and with minimal western-style environmental influences. The Linosa study was initiated identify susceptibility genes for common metabolic diseases such as T2D, obesity, hypertension, dyslipidemia. Our preliminary aim was to determine the overall prevalence of the major metabolic syndrome components in relation to the HOMA-IR-derived insulin-resistance (NCEP-ATP-III). The prevalence of subjects with impaired glucose regulation (IFG/IGT/T2D, according to ADA criteria) was 21.3% (n=75), with central obesity 28.1% (n=99), with hypertension 43.7% (n=154), with hypercholesterolemia 36.3% (n=128), with hypertriglyceridemia 28.1% (n=99), with “low HDL” 56% (n=197), with metabolic syndrome 9.4% (n=33), with no metabolic abnormalities 13% (n=46). Noteworthy, the prevalence of normal-weight subjects in the IFG/IGT/T2D group was high (22.6%, n=17). Furthermore, by determining the lower limit of the top quintile of HOMA-IR distribution (i.e. 2.35) in non-obese subjects with no metabolic disorders as the threshold for insulin-resistance (IR), the following IR prevalence rates were obtained: 62.6% (n=47) in IFG/IGT/T2D subjects, 72.7% (n=72) in central obesity, 48% (n=74) in hypertension, 49.2% (n=63) in hypercholesterolemia, 65.6% (n=65) in hypertriglyceridemia, 58.4% (n=115) in “low HDL” subjects, and 73% (n=24) in subjects with metabolic syndrome. In conclusion, these preliminary data from the Linosa population show a high prevalence rates of metabolic abnormalities in a low risk environment and their strong relationship with IR; therefore, an in depth genetic analysis of this unique islander population is highly warranted.