A Comparison of WHO and NCEP Criteria for the Diagnosis of Metabolic Syndrome in Chinese Population
Abstract Number: 1001-P
Authors: WEIPING JIA, KUNSAN XIANG, LEI CHEN, JUNXI LU, YUQIAN BAO, YUANMIN WU, SUYING JIANG
Institutions: Shanghai, China
Results: To compare the significance of the application of the working definition for metabolic syndrome(MS) proposed by WHO in 1999 and the one proposed by NCEP ATPIII(USA) in Chinese population. Data were gathered from crossectional survey in Shanghai from 1999 to 2001. 2048 subjects(men 896, women 1152) were enrolled. Plasma glucose, lipid profile, blood pressure, serum insulin, urine albumin and creatinine were all determined in these subjects. Insulin resistence was defined as the upper quartile of the distribution of the HOMA-IR(fasting glucose∗fasting insulin/22.5) among the background subjects(DM or IGR excluded). MS was diagnosed according to the definition proposed by WHO(1999) and NCEP ATPIII respectively. Our data showed: 1. According to the WHO(1999) and NCEP ATPIII definition, the age-adjusted prevalence of MS among population aged 20-74 years was 17.14% and 10.95% respectively, the former significantly higher than the latter. 2. The agreement in the diagnosis of MS using two definitions was about 45.17%. 42.02% of the subjects had MS only under the WHO(1999) definition, while 12.81% of the subjects had MS under NCEP ATPIII definition. 3. The prevalence of hyperglycemia and central obesity as defined by WHO(1999) definition was 1.74 and 4.38 times higher than those defined by NCEP ATPIII definition (16.74% vs 9.57%, 33.04% vs 7.54% respectively). 4. In comparison with non-MS subjects, the body mass index, waist-to-hip ratio, blood pressure, blood glucose, insulin resistant index(HOMA-IR) and albumin-to-creatinine ratio were all significantly increased in MS subjects. Conclusion: Both definitions for metabolic syndrome can reflect the clustering degree of risk factors of cerebrovascular and cardiovascular diseases. The WHO definition of MS can better reflect the characteristics of MS in Chinese than the definition proposed by NCEP ATPIII. However it needs more measurements and costs, therefore we should further explore a simple method with high detection ability.