Serum Albumin Level Is An Indicator Of Atherosclerosis With Differnet Pathogenesis
Abstract Number: 0956-P
Authors: MAYUKO KADONO, GOJI HASEGAWA, MASAKO SHIGETA, MICHIAKI FUKUI, TOSHIKAZU YOSHIKAWA, NAOTO NAKAMURA, Kyoto, Japan
Results: Nutritional status is one of the most important indicators of age-related physiological changes. Serum albumin level is a marker of nutritional status, and it has been reported to possess antioxidative properties. Serum albumin level is reduced in various diseased conditions, such as malnutrition and inflammation. On the other hand, it is increased in the individuals with obesity and metabolic syndrome which are considered to be linked to overnutrition. These findings suggest that serum albumin level contributes to atherogenesis. In the present study, we have sought to investigate the association between serum albumin level and atherosclerosis, as asseseed by brachial-ankle pulse-wave velocity (PWV), by analyzing the cross-sectional data from 2917 individuals, aged 23to 90 who underwent general health screening test. Subjects were excluded if they were treated with liver diseases, renal diseases.
In a multiple regression model, adjusted for variables including age, sex, body mass index, blood pressure, blood sugar, total cholesterol,serum CRP, smoking and drinking status, urinary protein, a U-shaped relationship between serum albumin level and PWV was statistically significant when serum albumin level was treated as a continuous variable in g/dl and centered at 4.4g/dl (quadratic term p value=0.006). Next, we assessed the prevalence of glucose dysmetabolism(FBS≥100mg/dl), metabolic syndrome according to the criteria of NCEP, and inflammation, across terteils of serum albumin. Inflammation was defined as serum CRP≥0.4mg/dl. The lowest tertile of serum albumin(3.3-4.2g/dl)was associated with reduced prevalence of glucose dysmetabolism with an adjusted odds ratio of 0.73(0.60 -0.88), compared to the middle tertile (4.3-4.6g/dl). The highest tertile (4.7-5.4g/dl) was associated with increased prevalence of metabolic syndrome with an adjusted odds ratio of 1.76(1.25-2.49), compared to the middle tertile, wheras the lowest tertile was associated with reduced prevalence of metabolic syndrome with an adjusted dds ratio of 0.61(0.45-0.82). Furthermore, the lowest terteile was associated with increased prevalence of inflammation with an adjusted odds ratio of 1.83(1.31-2.56).
These results demonstrated extremes of nutritional state were linked to atherosclerosis. Low serum albumin condition may increase the prevalence of atherosclerosis through reduced defence oxidative stress, and high serum albumin may link to metabolic syndrome, leading to atherosclerosis.